Detection of Nuclear Protein Profile Changes by Human Metapneumovirus M2-2 Protein Using Quantitative Differential Proteomics
Human metapneumovirus (hMPV) is a leading cause of lower respiratory infection in pediatric populations globally.This study examined proteomic profile changes in Brushes A549 cells infected with hMPV and two attenuated mutants with deleted PDZ domain-binding motif(s) in the M2-2 protein.These motifs are involved in the interruption of antiviral sig